I encountered a need to stream data using custom serial hardware that is accessed via a proprietary Java API. With fuse-jna, the API can be mapped into a file system that contains a file for each port.
The only difficulty was reading the data from the port. The read expects the implementation to fill the specified buffer. fuse appears to assume that a half filled buffer indicates EOF.
This problem was resolved by using direct-io, which is easily enabled in the open implementation.
A character based implementation using CUSE would presumably be a better match, but the fuse-jna project does not support it. An extensive search only found one usage of CUSE and a single example, indicating this functionality is probably orphaned.